Journal of Nuclear Agricultural Sciences ›› 2015, Vol. 29 ›› Issue (4): 699-703.DOI: 10.11869/j.issn.100-8551.2015.04.0699

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Research Progress of Radiation/ Desiccation Response Motif in Deinococcus radiodurans

WANG Yunguang, LI Tingting, WANG Liangyan, HUA Yuejin   

  1. Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, Zhejiang 310029
  • Received:2015-01-29 Revised:2015-03-12 Online:2015-04-13 Published:2015-04-16

耐辐射奇球菌中辐射/干燥响应基序的研究进展

王云光, 黎婷婷, 王梁燕, 华跃进   

  1. 浙江大学原子核农业科学研究所, 浙江 杭州 310029
  • 通讯作者: 华跃进, 男, 教授, 主要从事耐辐射奇球菌及真核细胞的DNA损伤响应机制及结构生物学的研究.E-mail:yjhua@zju.edu.cn
  • 作者简介:王云光, 男, 主要从事耐辐射奇球菌的DNA损伤响应机制研究.E-mail:wordlist@live.cn
  • 基金资助:
    国家自然科学基金(31210103904,31370102),中国农业部转基因生物新品种培育重大项目(2014ZX08009003-002-007)

Abstract: Deinococcus radiodurans is one of the discovered strongest stress-resistance bacteria, which has become an ideal model organism for the research of DNA damage response and repair mechanism. The radiation/desiccation response motif is a set of 17-bp conservative palindromic sequences spreading in many DNA damage response genes with different functions and involved in the resistance to ionizing radiation, oxidative damage and desiccation. Combined our novel research findings with the national and international relative literatures in this fireld, we summarized the research progress of radiation/desiccation response motif, demonstrated the DNA damage response pathways involved, and further described the prospect of its potential function, significance and application.

Key words: Deinococcus radiodurans, radiation/desiccation response motif, DNA damage response, operon

摘要: 耐辐射奇球菌是迄今为止被发现抗逆性最强的极端生物之一, 是研究DNA损伤应激响应与修复机制的较为理想模式生物.其中的辐射/干燥响应基序是一组相对保守的17-bp长的回文序列, 广泛地分布在众多不同功能的DNA损伤响应基因中, 与抗电离辐射、氧化损伤及干旱等有关.本文结合该领域以往的研究文献与最新研究, 探讨了耐辐射奇球菌中辐射/干燥响应基序的研究进展, 阐释了其所涉及的DNA损伤应激响应通路, 并且进一步展望了其潜在的生物学功能、意义与应用.

关键词: 耐辐射奇球菌, 辐射/干燥响应基序, DNA损伤应激响应, 操纵子